Author: daniel@danielkjung.com

  • How an academic betrayal led me to change my authorship practices

    How an academic betrayal led me to change my authorship practices

    The day the paper was published should have been a moment of pride. Instead, it felt like a quiet erasure. There it was: the data set I had helped shape, the computer scripts I had debugged and refined, the analytical framework I had spent months developing—all neatly embedded in a peer-reviewed journal article. But my name was absent. The feeling of exclusion was painful enough—but what stung more was that I had seen it coming, yet had felt powerless to stop it.

    In 2020, during my doctoral studies at a major European university, a more senior Ph.D. student asked for help coding the analysis for his thesis. We had several in-depth discussions about the work, and he promised me co-authorship if the results were published. He even suggested the outcomes might fit into a chapter of my own dissertation, and that he would inform my supervisors once the work matured. I believed him.

    Over the next year, I invested hours of focused effort into writing, modifying, and validating the scripts that underpinned the analysis. But crucially, the collaboration remained informal. Most conversations happened over voice calls. Any emails I sent went unacknowledged. There was no official record of our agreement or the work’s scope. In hindsight, I now see that this lack of documentation was not an accident—it was deliberate.

  • Morpholino-mediated splicing of FOXP3 for cancer immunotherapy

    Morpholino-mediated splicing of FOXP3 for cancer immunotherapy

    Reprogramming intratumoral Treg cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapy

    Editor’s summary

    The master regulator of regulatory T (Treg) cells, FOXP3, is present in humans as two major variants, including a shorter isoform lacking exon 2 (FOXP3dE2). Li et al. found that mice expressing the FOXP3dE2 isoform were resistant to the growth of multiple tumor types. Tumor-infiltrating Treg cells from Foxp3dE2 mice were less suppressive of CD8 T cell responses and produced higher levels of effector cytokines, including IFN-γ. A morpholino oligo that induced the skipping of FOXP3 exon 2 slowed growth of tumors in mice and organoids derived from patients with breast or colorectal cancer. These findings suggest that targeting FOXP3 isoform usage could be an approach to alleviate Treg cell–mediated tumor immunosuppression. —Claire Olingy

  • Analysis of stress-induced small proteins in Escherichia coli reveals that YoaI mediates cross-talk between distinct signaling systems

    Analysis of stress-induced small proteins in Escherichia coli reveals that YoaI mediates cross-talk between distinct signaling systems

    Editor’s summary

    Bacterial small proteins regulate diverse cellular activities and responses to environmental stimuli. Vellappan et al. identified small proteins induced by Mg2+ starvation in Escherichia coli and investigated their mechanisms of induction, subcellular localization, and effects on cell growth. One of these, YoaI, mediated cross-talk between the PhoR-PhoB and EnvZ-OmpR two-component signaling systems, which control cellular responses to phosphate starvation and osmotic stress, respectively. These findings expand the known repertoire of stress-induced small proteins that regulate bacterial adaptive signaling. —Annalisa M. VanHook

  • Understanding the Digital Health Journal: A Comprehensive Guide

    What is a Digital Health Journal?

    A digital health journal is an innovative tool that enables individuals to track and manage their health and wellness using technology. This journal can encompass various aspects of health, including medication adherence, physical activity, nutrition, and mental well-being, all documented digitally. As the focus on personal health increases, the significance of maintaining a digital health journal has become more pronounced.

    Benefits of Keeping a Digital Health Journal

    One of the primary advantages of utilizing a digital health journal is the ease of access and organization. Users can effortlessly log their daily activities and health metrics, allowing for better insights over time. Additionally, many digital health journals offer data visualization tools that make it simpler to identify trends and patterns in one’s health journey. This accessibility empowers individuals to take control of their health proactively.

    How to Get Started with Your Own Digital Health Journal

    Starting your digital health journal is a straightforward process. Begin by selecting a suitable app or platform that meets your needs. Ensure it includes features that allow you to record various health metrics tailored to your lifestyle. Set daily reminders to maintain consistency in logging your data. Over time, review your entries to gain insights into your health, making adjustments to your routines as necessary. By integrating a digital health journal into your daily life, you can foster a more informed and healthier lifestyle.